---
title: Clinical Studies | Silver Dressings | Silverlon
---

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[**MEDICAL PROFESSIONAL**](https://www.silverlon.com/products/medical-professionals)

**[MILITARY](https://www.silverlon.com/products/military)**

[**CONSUMERS**](https://www.silverlon.com/products/consumers)

**ANASEPT  
**[Irrigation Solution](https://anacapa-tech.net/product/anasept-antimicrobial-wound-irrigation-solution/)  
[Wound Cleanser](https://anacapa-tech.net/product/anasept-antimicrobial-wound-cleanser/)  
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# Clinical Studies

Multiple, peer-reviewed, published studies have shown the effect that Silverlon can have. Studies in a wide variety of Surgical, Wound and Burn Care settings. Explore the studies behind the most advanced, evidence-based antimicrobial dressings available today.

- [All](https://www.silverlon.com/resources/clinical-studies#all)
- [Surgical](https://www.silverlon.com/resources/clinical-studies#surgical)
- [Central Line Catheter](https://www.silverlon.com/resources/clinical-studies#central-line-catheter)
- [Wounds](https://www.silverlon.com/resources/clinical-studies#wounds)
- [Negative Pressure Wound Therapy](https://www.silverlon.com/resources/clinical-studies#negative-pressure-wound-therapy)
- [Burns and Military](https://www.silverlon.com/resources/clinical-studies#burns-and-military)
- [Silver in Medicine](https://www.silverlon.com/resources/clinical-studies#silver-in-medicine)

#### Decreasing Utilization of Indwelling Urinary Catheters Using Creative Strategies

Authors: Jeannine W.C. Blake, PhD RN1; Ellie Milo, DNP RN CENP NEA-BC2; Robert Garcia, BS, MT(ASCP), CIC, FAPIC3

**Christus Santa Rosa Hospital**

Publication: Elaine Mareib Center for Nursing and Engineering Innovation, University of Massachusetts Amherst; Chief Nursing Officer, Christus Santa Rosa Westover Hillss; Enhanced Epidemiology LLC

[Download →](https://www.silverlon.com/hubfs/Christus%20Poster%20APIC_051724.pdf)

#### PEG TUBE DISLODGEMENT: REDUCING HARM THROUGH INNOVATIVE PRODUCT AND PROCESS CHANGE

Authors: Amanda Ross, RN; Jeannine Blake, PhD RN

**Memorial Hermann Southwest**

[Download →](https://www.silverlon.com/hubfs/NTI%20Poster-PEG%20Tube%20Dislodgement%20Final_v5%20No%20QR%20Code%20No%20Product%20Pic%5B29%5D.pdf)

#### ECMO Care Beyond Decannulation: A Nurse Driven Wound Care Protocol

Authors: Audrey Basic1, Emily Smith1, Jonathon Holte2, Sylvie Baudart3, Jason Smith4 

**University of California at San Francisco**

Publication: Intensive Cardiac Care1, Institute for Nursing Excellence2,Mechanical Circulatory Support3, Department of Cardiothoracic Surgery4

[Download →](https://www.silverlon.com/hubfs/ISHLT2024Poster%20%20ECMO%20Decannulation%20sites%20final.pdf)

#### A Silver Lining in the VAD Sky: A Prospective Randomized Controlled Driveline Dressing Study

Authors: Sylvie Baudart1, Liviu Klein2

**University of California at San Francisco**

Publication: Department of Mechanical Circulatory Support, Advanced Heart Failure Comprehensive Care Center

[Download →](https://www.silverlon.com/hubfs/ISHLT2024SIlverfinal.pdf)

#### Modified Sodium Hypochlorite Wound Cleansing for Chronic Wounds: Focused Clinical Literature Review

Authors: Karen K. Giuliano, RN, PhD1, Bill Richlen PT, WCC, DWC2, Charlie P. Buscemi, PhD, APRN, CWCN, WOCNF3

**University of Massachusetts Amherst; Wound Care Gurus; Florida International University. Miami, FL**

Publication: Florida International University

[Download →](https://www.silverlon.com/hubfs/SAWC%20Poster%202024%203.16.24%20v3.pdf)

#### Silver-Plated Wound Dressings for the Management of Radiation Dermatitis in Head and Neck Cancer

Authors: Cody R Kilar, DO, PhD1, Christopher Knoth, MD2, Alexis Warden PA-C3, David A Clump, MD, PhD4

**Department of Radiation Oncology, West Virginia University Cancer Institute, Morgantown, West Virginia**

Publication: WVU Cancer Institute 

[Download →](https://www.silverlon.com/hubfs/Documents/ONS%20poster%203.16.24%20%20-%20.pdf)

#### Patient Perspectives on Novel Intervention for Radiation Dermatitis

Authors: Phylicia Gawu, D.O.1, Oluwatomiwa Awobayiku, BS2, Alekhya Mitta M.D.3, Christina Henson M.D.4

**The University of Oklahoma Health Sciences Center, Stephenson Cancer Center; New York Institute of Technology College of Osteopathic Medicine at Arkansas State University**

Publication: InitialPatient Perspectives on a Novel Intervention for Radiation Dermatitits: A Single Institutional Experience 

[Download →](https://www.silverlon.com/hubfs/Documents/Clinical%20Studies/ACRO%20OU%20poster%20PG%20edits.pdf)

#### Silverlon: A Weapon Against Driveline Infections in Lvad Patients

Authors:K.R. Barrett,1 B. Ebert,2 and M. Remaly.3

**Lehigh Valley Health Network, Allentown, PA; Lehigh Valley Health Network, Harleysville, PA; and the Lehigh Valley Hospital, Germansville, PA.**

The Journal of Heart and Lung Transplantation, Vol 42, No 4S, April 2023

[Download →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hubfs/Documents/Clinical%20Studies/Lehigh%20Valley%20LVAD%20Study%202023.pdf>

#### Use of a Silver Nylon Dressing Following Total Hip and Knee Arthroplasty Decreases the Postoperative Infection Rate

Authors: Ashley J. Tisosky MD1, Otatade Iyoha-Bello BSc2, Nicholas Demosthenes BA3, Giovanni Quimbayo MD2, Tara Coreanu BSc4, Ayesha Abdeen MD FRCSC5

**Harvard Combined Orthopaedic Residency Program, Massachusetts General Hospital, Boston, MA, USA**

Publication: JAAOS - Journal of the American Academy of Orthopaedic Surgeons (2017)

Download →

<https://www.silverlon.com/hubfs/Harvard%20Silverlon%20Study%20Use%20of%20Silver%20Nylon%20Dressing%20Following%20Total%20Hip%20and%20Knee%20Arthroplasty.pdf?t=1526501491569>

surgical

#### The Use of Silver Nylon in Preventing Surgical Site Infections Following Colon and Rectal Surgery

Authors: Beth Krieger MD, Donald M. Davis MD, Jaime E. Sanchez MD, James J. Mateka, Valentine N. Nfonsam MD, Jared C. Frattini MD, Jorge E. Marcet MD

**University of South Florida, Tampa, FL, USA **

Publication: Diseases of the Colon & Rectum (2011)

[Download →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hs-fs/file-1138413215-pdf/docs/Silver_Dressings_Colon_Rectal_Surgery_2011.pdf?t=1526501491569>

surgical

#### Reduction in Central Line–Associated Bloodstream Infections Correlated With the Introduction of a Novel Silver-Plated Dressing for Central Venous Catheters and Maintained for 6 Years

Authors: Rachel Karlnoski PhD1, Elia Charbel Abboud MD1, Peggy Thompson BSN CIC FAPIC2, Asa Z. Oxner MD3, John T. Sinnott, MD FACP4, Jorge E. Marcet MD FACS FASCRS1

**Tampa General Hospital, Tampa, FL, USA **

Publication: Journal of Intensive Care Medicine (2017)

 Download[ →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hubfs/docs/IVCD%20Study%20Tampa%20General%20Reduction%20in%20Central%20Line-Associated%20Bloodstream%20Infections%20Correlated%20with%20Introduction%20of%20Novel%20Silver-Plated%20Dressing.pdf?t=1526501491569>

central-line-catheter

#### A Clinical Trial to Investigate the Effect of Silver Dressings on Mediastinitis Rates in Postoperative Cardiac Sternotomy Incisions

Authors: Roger Huckfeldt MD FACS, Clyde Redmond MD, Debbie Mikkelson BSM, Phillip J. Finley MS, Cindy Lowe BS CCRP, Jennifer Robertson RN

**St John’s Regional Health Center, Springfield, MO, USA**

Publication: Ostomy Wound Management (2008)

Download →

<https://www.silverlon.com/hs-fs/file-1138418265-pdf/docs/silver-dressing-effect-mediastinitis.pdf?t=1533870046392>

surgical

#### Do Silver-Impregnated Dressings Limit Infections After Lumbar Laminectomy with Instrumented Fusion?

Author: Nancy E. Epstein MD

**Albert Einstein College of Medicine, Bronx, NY, USA**

Publication: Surgical Neurology (2007) 

Download →

<https://www.silverlon.com/hs-fs/file-1138413205-pdf/docs/silver_dressings_lumbar_laminectomy.pdf?t=1533870046392>

surgical

#### Silver Negative Pressure Dressing With Vacuum-assisted Closure of Massive Pelvic and Extremity Wounds

Authors: Herrick J. Siegel MD, Diego F. Herrera MD, Jason Gay CRNFA

**University of Alabama at Birmingham (UAB), Birmingham, AL, USA**

Publication: Clinical Orthopaedics and Related Research (2013)

 Download →

<https://www.silverlon.com/hs-fs/hub/173839/file-2567272379.pdf?t=1526501491569>

negative-pressure-wound-therapy, wounds

#### Military Applications of Silver-Nylon Dressings

Author: David J Barillo MD FACS FCCM

**Winchester Medical Center, Winchester VA, USA **

Publication: BURNS: The Journal of the International Society of Burn Injuries (2014) 

[Download →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hs-fs/file-1132864043-pdf/docs/Silverlon_Military_Applications_of_Silver_2011.pdf?t=1526501491569>

burns-and-military

#### Silver In Medicine: The Basic Science

Authors: David J Barillo, MD FACS FCCM, David E. Marx DVM

**University of Scranton, Scranton, PA, USA**

Publication: BURNS: The Journal of International Society of Burn Injuries (2014) 

Download →

<https://www.silverlon.com/hs-fs/file-2573233715-pdf/docs/SilverInMedicine_TheBasicScience.pdf?t=1533870046392>

surgical, central-line-catheter, wounds, negative-pressure-wound-therapy, burns-and-military, silver-in-medicine

#### Silver in Medicine: A Brief History BC 335 to Present

Authors: David E. Marx DVM, David J Barillo MD FACS FCCM

**University of Scranton, Scranton, PA, USA**

Publication: BURNS: The Journal of International Society of Burn Injuries (2014) 

[Download →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hs-fs/file-2558876313-pdf/docs/SilverInMedicine_ABriefHistory.pdf?t=1526501491569>

surgical, central-line-catheter, wounds, negative-pressure-wound-therapy, burns-and-military, silver-in-medicine

#### A Clinical Evaluation of Silverlon® Wound Contact Layer Antimicrobial Wound Dressing

Author: Gareth Owen

**Manchester Royal Infirmary, UK**

Download →

<https://www.silverlon.com/hs-fs/file-1138628290-pdf/docs/clinical_evaluation_silverlon_wcl.pdf?t=1526501491569>

wounds

#### Left Ventricular Assist Devices: An Innovative Approach to Decrease Infections Using a Silver Contact Dressing

Author: Joan Lerner Selekof BSN RN CWOCN

**University of Maryland Medical Center, Baltimore, MD, USA**

Presented at Mid Atlantic Region Wound Ostomy and Conference Nurses Annual Conference (2010)

Download →

<https://www.silverlon.com/hs-fs/file-1135035856-pdf/docs/silver-dressings-reduce-driveline-site-infections.pdf?t=1533870046392>

central-line-catheter

#### Healing Chronic, Ischemic, Infected Saphenous Vein Harvest Sites in the Legs with Silver Plated Cloth and Allograft Dermal Regenerative Matrix

Authors: Stanley Carson MD FACS, Eric Travis DPM, Carol Ajifu PT, DIana To MPT

Download →

<https://www.silverlon.com/hs-fs/file-1138418260-pdf/docs/silver-dressings-heal-infected-saphenous_vein_harvest-sites.pdf?t=1533870046392>

surgical

#### Silver-Based Dressings for the Reduction of Surgical Site Infection: Review of Current Experience and Recommendation for Future Studies

Authors: Elia Charbel Abboud MD, Judson C. Settle MD, Timothy B. Legare MD, Jorge E. Marcet MD, David J. Barillo MD, Jaime E. Sanchez MD

**University of South Florida, Tampa, FL, USA**

Publication: BURNS: The Journal of the International Society of Burn Injuries

Download →

<https://www.silverlon.com/hs-fs/file-2566739564-pdf/docs/Silver-BasedDressingsForTheReductionOfSurgicalSiteInfection.pdf?t=1533870046392>

surgical

#### Silver-Resistance, Allergy, and Blue Skin: Truth or Urban Legend?

Author: Dr. Jose P. Sterling, MD

**St. Vincent Regional Medical Center, Santa Fe, NM, USA**

Publication: BURNS: The Journal of the International Society of Burn Injuries (2014)  
 

Download →

<https://www.silverlon.com/hs-fs/file-2562622757-pdf/docs/Silver-resistance_allergy_blues_skin.pdf?t=1533870046392>

surgical, central-line-catheter, wounds, negative-pressure-wound-therapy, burns-and-military, silver-in-medicine

#### Wound Healing and Cost-Saving Benefits of Combining Negative-Pressure Wound Therapy with Silver

Authors: Jeffrey C. Karr DPM, Fernando Loret de Mola MD, Tri Pham MD, Leslie Tooke RN

**The Wound Care Center at Lakeland Regional Medical Center, Lakeland, FL, USA**

Publication: Advances in Skin & Wound Care (2013)

Download →

<https://www.silverlon.com/hs-fs/file-2567282544-pdf/docs/WoundHealingandCostSavingBenefits.pdf?t=1533870046392>

negative-pressure-wound-therapy

#### Utilizing Silver Plated Fabric With Negative Pressure Wound Therapy Poster

Author: Tina Baum, MS, CNS, ACNS-BC, CWON

**Florida Hospital North Pinellas**

Download →

<https://www.silverlon.com/hubfs/Documents/utilizing-silver-plated-fabric-with-negative-pressure-wound-therapy-tina-baum-poster.jpg>

negative-pressure-wound-therapy

#### Silverlon® use in Afghanistan for Burn Care

Authors: Mary-Margaret Brandt MD, Margaret Tait MT (ASCP), Thomas Toddanio MA MT (ASCP), Wendy Wahl MD

**University of Michigan Burn Center, MI, USA**

Download →

<https://www.silverlon.com/hs-fs/file-2569764249-pdf/docs/Silverlon_in_Afghanistan_2003_11p.pdf?t=1533870046392>

burns-and-military

#### Comparison of Silverlon® Dressing to Xeroform™ Gauze in the Treatment of Skin Graft Donor Site Wounds

Authors: Michale C. Albrecht MD, Evan Renz MD, Leopoldo C. Cancio MD, Christopher E. White MD, Lorne H. Blackbourne MD, Kevin Chung MD, Eric E. Horvath DO, Peggy Bielke RN, David Baer PhD, Steven E. Wolf MD, John B Holcomb MD

**U.S. Army Institute of Surgical Research, Fort Sam Houston, TX, USA**

Download →

<https://www.silverlon.com/hs-fs/file-2554916906-pdf/docs/ComparisonofSilverlonDressingtoXeroformGauze.pdf?t=1533870046392>

burns-and-military

#### A Literature Review of the Military Uses of Silver-Nylon Dressings with Emphasis on Wartime Operations

Author: David J Barillo, MD, FACS, FCCM

**Department of Surgery, St. Joseph Mercy Hospital-Ann Arbor, Ann Arbor, MI, USA**

Download →

<https://www.silverlon.com/hs-fs/file-2558891528-pdf/docs/ALiteratureReviewOfTheMilitaryUses.pdf?t=1533870046392>

burns-and-military

#### Chronic, Diabetic Foot Wounds with Ischemia and Tissue Loss: Use of Advanced Wound Care Techniques, Silver Plated Cloth, Allografts and Vascular Intervention to Prevent Further Tissue Loss

Authors: Dr. Stanley N. Carson MD FACS, Eric Travis DPM, Diana To MPT

**Fountain Valley Regional Hospital, Fountain Valley, CA, USA**

Download →

<https://www.silverlon.com/hs-fs/file-1135035881-pdf/docs/Diabetic_Foot_Wounds_Ischemia.pdf?t=1533870046392>

wounds

#### Treatment of Pyoderma Gangrenosum with a Silver Contact Layer

Author: Dr. Carl Van Gils

**Dixie Regional Medical Center Wound Clinic, St. George, UT, USA**

Download →

<https://www.silverlon.com/hs-fs/file-1135035886-pdf/docs/Van_Gils_Pyoderma_Study.pdf?t=1533870046392>

wounds

#### The Effect of Blast-Related Burn Injuries from Prolonged Field Care to Rehabilitation and Resilience

Authors: Charles C. Engel, Ryan K. McBain, Samantha McBirney, Sara E. Heins, Molly M. Simmons, Emily Hoch, Mimi Shen, Nicholas Broten, Gulrez Shah Azhar, Tepring Piquado

**RAND Corporation**

[Learn More →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hubfs/Documents/Clinical%20Studies/RAND_RRA807-1%20(2).pdf>

burns-and-military

#### Reduce Driveline Trauma Through Stabilization and Exit Site Management: 30 Days Feasibility Results from the Multicenter RESIST Study

Authors: Marcia Stahovich, Kartik S. Sundareswaran, Sarah Fox, William Hallinan, Peggy Blood, Leway Chen, Salpy V. Pamboukian, Raymond Chinn, David J. Farrar, Francis D. Pagani, Laura Blue

**ASAIO Journal 2016**

[Learn More →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hubfs/Documents/Clinical%20Studies/RESIST%20-Reduce_Driveline_Trauma_Through_Stabilization_and.4.pdf>

central-line-catheter

#### Silver-plated Discs at PICC Insertion Sites in the Neonatal ICU

Authors: Gloribel Medina, MHA, MPH, BSN, RNC-NIC, Karen Fugate, MSN, RNC-NIC, CPHQ, Kimberly Atrubin, MPH, CIC, CPHQ, FAPIC

**Children's Medical Center, Tampa General Hospital, Tampa, FL, USA**

[Learn More →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hubfs/Documents/Clinical%20Studies/TGH%20NICU%20Study%20One%20Sheet%20v2%20ac4%20111820.pdf>

central-line-catheter

#### The Use of a Silver-Nylon Dressing During Evacuation of Military Burn Casualties

Authors: Amit Aurora, D.Eng., Alexander Beasy, BA, Julie A. Rizzo, MD, Kevin K. Chung, MD

**Original Article**

[Learn More →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hubfs/Documents/Clinical%20Studies/Silverlon%20in%20mil%20evacuation%20(1).pdf>

burns-and-military

#### Non-Inferiority of a Novel Silver-Plated Dressing for Central Venous Catheters: A retrospective Cohort Evaluating Rates of Central Line-Associated Bloodstream Infections in Adult Intensive Care Patients

Authors: Asa Oxner MD, Andrew Myers MD, John Sinnot MD, FACP, Jorge Marcet MD, Jillian Sajdak, Peggy Thompson BSN, CIC, Charles Myers

**University of South Florida College of Medicine**

[Download →](https://www.silverlon.com/resources/clinical-studies#)

<https://www.silverlon.com/hs-fs/file-1138628295-pdf/docs/Lifesaver_Dressing_Study.pdf?t=1531758674754>

central-line-catheter

## Please note:

These studies may involve findings that exceed the claims currently cleared by the FDA for the product. Argentum Medical, LLC is not intending to make performance claims about its product. The intent is to disseminate the scientific literature on these products. We encourage you to read these studies to understand the strengths and limitations of the data. For some claims, Argentum is seeking to broaden the indications with the FDA in the future using data, such as these studies, to provide the substantiation.

### Put Silverlon to the test in your operation.

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