Advanced Antimicrobial Wound, Burn, and Surgical Care Products
Silverlon® Dressings General Considerations

Radiographic Imaging Studies

Plain Radiographic and CT Images

The Silverlon^® fabric is relatively radio-opaque and will obscure underlying osseous and soft tissue structures.

MRI Scans

Silverlon^® Wound Dressings applied to open wounds are not compatible with Magnetic Resonance Imaging (MRI) Scanners.

• For maximum antimicrobial activity, the silver surface of the Silverlon^® Dressings is applied directly to the wound surface.
• Silverlon^® Contact Dressing has a shinny and a dull surface: either the shinny or the dull surface may be placed against the wound surface.
• Silverlon^® Pad Dressing has a white side and a silver side: the silver side is placed against the wound surface.

Silverlon® Side Absorbency Pad	Side with Slits

• Non-medicated wound contact dressings such as the Owens Dressing, Dermanent, Tegapore, Drynet^®, and Profore^® Wound Contact, may be placed between the Silverlon^® and the wound surface, although the maximum antimicrobial effect of Silverlon^® is achieved by placing Silverlon^® directly on the wound surface.
• Medicated wound contact dressings such as Adaptic^® (impregnated with petrolatum emulsion) placed between the Silverlon^® and the wound surface, significantly decreases antimicrobial activity of the dressing.
• Enzymatic debriding agents such as Panafil^®, Santyl^® and Accuzyme^® are not recommended to be used with Silverlon^® since papain may be inactivated by metal ions.
• Antibiotic creams (e.g. silver sulfadiazine) placed between the Silverlon^® and the wound surface decreases the silver ion antimicrobial activity of the dressing.
• Recombinant human derived platelet-derived growth factor, Regranex^®, may be applied as directed with water.
• Overlapping normal periwound skin by 1 to 2 centimeters appears to enhance the analgesic effect of the Silverlon^® Dressings.

• All Silverlon^® Dressings should be moistened initially and every 12 to 24 hours with sterile water if the dressing becomes dry.
• Silverlon^® Contact Dressings require a covering dressing to assist with providing a moist wound environment.
  

• Multiple 5 mm slits have been placed through the film urethane of the Silverlon^® Pad Dressing to allow easy wetting without removing or lifting the dressing from the wound site.
• If the Silverlon^® fabric is allowed to dry out, no silver ions will be released and the effectiveness of the product will be decreased.
• Keeping the Silverlon^® Dressings moist reduces the adhesiveness of the dressing to the wound surface.

5mm Slits on Silverlon Pad Dressing	Wetting the Pad with Water

• The length of time the Silverlon^® Products may be applied is dependent upon wound effusion and debris. When the silver plated fibers are covered with cellular debris (as seen in the below scanning electron micrographs), the passive silver ion release is decreased and the antimicrobial effectiveness of the Silverlon^® burn dressings is decreased.

            Silverlon^® Burn Dressing From a Highly Exudative Full Thickness Wound

• Provided that the Silverlon^® fibers are not covered with cellular debris and wound exudates, silver ions continue to be released up to for seven days.

Silver Ion Release

The release of silver ions into tryptic soy broth is noted below for the Silverlon^® Burn Contact Dressing 4 inch by 4 inch and the Silverlon^® Burn Pad 4 inch by 4 inch. 20 August 2001. Data on file.

Rapid MRSA and Pseudomonas Antimicrobial Activity

The antimicrobial activity of the Silverlon^® Burn Contact Dressing 4x4 was evaluated by the “Antimicrobial Activity Dynamic Test of Surfaces” ASTM E2149 for 10⁶ CFU/ml of Pseudomonas aeuroginosa ATCC 9027 and Staphylococcus aureus (MRSA) ATCC 33591. Study was completed by NAMSA, 3400 Cobb International Blvd., Kennesaw, GA. Lab No. 02G 00949 00, 21 February 2002. Data on file.

Silverlon^® Organism Count Reduction versus Time

Skin Discoloration and Tattooing

Silverlon^® Dressings have not been reported to cause skin tattooing or transient discoloration. Metallic silver is not deposited into wound tissues.

Infant Application

Silverlon^® Dressings may be applied to infants and pediatric patients.

General Precautions

• The product should not be implanted and is for external use only.
• Store at room temperature, avoid temperatures above 122^o F (50^o C).
• Dressings are not compatible with products containing chlorine, petrolatum, iodine, or hydrogen peroxide.
• The Silverlon^® Dressings have been reported to reduce the pain from acute incisions. With a reduction in wound pain, some patients will have a tendency to over activity prior to stability of the wound site.

General Contraindications

• Silverlon^® dressings are contraindicated for patients with known sensitivity to silver or nylon.

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All of the Silverlon® Wound Care, Burn Care, and Surgical Products listed on this website are FDA Cleared. Copyright © 1998-2010 Argentum Medical, LLC. All Rights Reserved.

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